Isoliquiritin has significant pharmacological activity. It not only has an anti-ulcer effect, but also has a certain inhibitory effect on monoamine oxidase. It can be used to treat depressive psychosis. Isoglycyrrhizin is a promising natural drug, so its extraction into separation industry and clinical research has received increasing attention from scholars at home and abroad. At present, the method for separating isoglycyrrhizin by macroporous adsorption resin adsorption has been widely studied by scholars.