Hawthorn flavonoids are brown-red powders. The plant source is the mature fruit of the hawthorn plant. It can expand coronary artery, increase coronary flow, protect myocardial ischemia and hypoxia; and can strengthen heart, lower blood pressure and anti-arrhythmia, lower blood fat, anti-atherosclerosis and increase cholesterol excretion. The extraction of hawthorn flavonoids by macroporous adsorption resin is an ideal choice. The method has the advantages of simple equipment, easy operation and high product purity, and has good application prospects.