Rhubarb is a traditional Chinese medicine in China. It has the effects of clearing away heat, cooling blood and detoxifying, and has broad-spectrum antibacterial and anti-viral tumor effects. Rhubarb is the main medicinal ingredient. The traditional preparation method makes the active ingredient in the paste lower, and the content of ineffective ingredients and impurities is high, which limits the application of rhubarb in the preparation with strict requirements. At present, macroporous adsorption resin can effectively obtain an effective substance of scorpion in rhubarb.