Proanthocyanidins have a wide range of biochemical and pharmacological activities and are widely used in medicine, cosmetics and health foods. Grape seed is generally considered to be a good source of extracting proanthocyanidins, but the crude anthocyanin content in grape seed extract is low and needs further separation and purification. Among various separation methods, the macroporous resin adsorption elution method developed in recent years has the advantages of good selectivity, large adsorption capacity, high mechanical strength, fast adsorption speed, good separation effect, convenient regeneration treatment, etc., and industrialization of natural products. Widely used in extraction and separation.