Specifications

Isoliquiritigenin
Licorice Extract
Isoliquiritigenin CAS:961-29-5

English name:Isoliquiritigenin

 

 

Orginal plant: Glycyrrhizae root

 

Purity:HPLC98%

 

CAS NO. :961-29-5

 

 

Molecular formula:C15H12O4

 

Molecular weight:256.25

 

Quality data

 

 

Identification	Standardization
Aspect	Brown yellow fine powder
Odor & taste	Characteristic
Particle size	NLT 95% through 80 meshes
Loss on drying	5.0% max.
Sulphated ash	5.0% max.
Heavy metals	20ppm max.
Pb	2ppm
As	2ppm

 

Microbiological data

Total aerobic count	Not more than 1000cfu/gram
Yeast & Mold	Not more than 100cfu/gram
E. Coli	Absence in 10g
Salmonella	Absence in 10g

Addition data

Sterilization	High temperature and press
Storage	Store in a cool dry place, avoiding sunlight directly
Shelf life	Two years when sealed well
Packaging	Food grade multiplayer polyethylene bags, 25kg in one type cardboard drum

 

Isoliquiritigenin is a natural flavonoid isolated from licorice, shallot and bean sprouts. The effect of isoliquiritigenin on cell proliferation and cell cycle progression was examined in the A549 human lung cancer cell line. Isoliquiritigenin significantly inhibited the proliferation of lung cancer cells in a dose- and time-dependent manner. Flow cytometric analysis demonstrated that isoliquiritigenin restrained the cell cycle progression at G2/M phase. Further examinations using cDNA arrays and real-time quantitative RT-PCR revealed that isoliquiritigenin enhanced the expression of p21CIP1/WAF1, a universal inhibitor of cyclin-dependent kinases. These results suggest that isoliquiritigenin will be a promising agent for use in chemopreventive or therapeutics against lung cancer.