Product Details

Megestrol Acetate is the acetate salt form of megestrol, a synthetic derivative of the naturally occurring female progesterone with potential anti-estrogenic and antineoplastic activity.

Megestrol acetate, a progestational agent, is frequently used in the treatment of patients with metastatic breast cancer. It is generally well tolerated, except that it may cause undesirable weight gain. Subsequently, it was shown that megestrol acetate produced weight gain in a variety of cachectic cancer patients. Significant reduction inserum levels of IL-1a and b,IL-2,IL-6, and TNF-o were observed in cancer patientstreated with megestrol acetate which may bear on the mechanism of improved appetite and body weight gain.It has also been postulated that the effect is, at least in part,mediated by NPY,a potent central appetite

CAS	595-33-5
Product Name	Megesgtrol Acetate
Density	1.15
Melting Point	214ºC
Boiling Point	507.1°Cat760mmHg
Refractive Index	11 ° (C=2, CHCl3)
Flash Point	218.5°C
PSA	60.44000

Product Name: megestrol acetate

CAS No.: 595-33-5

Items	Standards	Results
Appearance	White or off-white solid powder	Complies
Identification	By IR	Complies
Identification	By HPLC	Complies
Solubility	Soluble in DMF, sparingly soluble in THF, slightly soluble in methanol and acetonitrile, very sightly soluble in ethanol and dichloromethane, insoluble in water	Complies
Polymorphic Form	Polymorphic form 1	Complies
Melting Point	211ºC~216ºC	212.8ºC~214.9ºC
Water Content	≤ 0.50%	0.10%
Heavy Metals	≤ 20ppm	Complies
Residue on Ignition	≤ 0.20%	0.09%
Related Substance	Any single impurity: ≤0.10%	0.06%
Related Substance	Total Impurities: ≤1.00%	0.16%
Assay (on the anhydrous basis)	98.0%~102.0%	99.94%
Particle Size	D90: ≤100µm	Complies
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight,light-resistant containers in a cool place