The collecting property of <a href="CF">">CF Chelate Collector</a> to gangue minerals such as calcium, magnesium, iron, silicon has been studied primarily and systematical researches have been done on various influence factors during flotation of oxide Pb-Zn minerals. The results show that <a href="CF">">CF collector</a> is an effective collector to <a href="smithsonite">smithsonite</a> and white lead, good <a href="selectivity">selectivity</a> to calcite, dolomite, quartz and limonite.