Product Description
Suppository refers to a solid preparation of a drug and a suitable matrix for intracavitary administration. The suppository is
solid at normal temperature. After being inserted into the cavity, it can rapidly soften or dissolve in the secretion at body
temperature, and gradually release the drug to produce local or systemic effects. In the early days, it was thought that
suppositories only played a local role such as lubrication, convergence, antibacterial, insecticidal, local anesthesia, etc.
Later, it was found that suppositories can still exert systemic effects through rectal absorption of drugs, and can avoid the
first-pass effect of the liver.
Differently divided into rectal, vaginal, urethral suppositories, such as anal plugs, vaginal suppositories, urethral plugs,
dental plugs, etc., the most commonly used are anal plugs and vaginal plugs. In order to adapt to the application site of the body, the properties and weight of the suppository are different, and generally have clear regulations.
1 )anal plug The anal plug has a conical shape, a cylindrical shape, a torpedo shape and the like. Each weight is about 2g, 3-4cm long, and about 1g for children. Among them, the shape of the torpedo is better, and after being inserted into the anus, it is easily pressed into the rectum due to contraction of the sphincter. The drug in the anal plug can only exert a local therapeutic effect.
2） vaginal suppository vaginal suppository has a spherical shape, oval shape, duckbill shape, etc., each weight about 2-5g, diameter 1.5-2.5cm, which has the largest surface area of the duckbill.
3 ) urethral plug has men and women, male weight of about 4g, length 1-1.5cm; female weight of about 2g, length 0.60-0.75cm. The weight of the above suppository is made of cocoa butter, and the weight of the suppository is different if the specific gravity of the matrix is different.
According to the preparation process and release characteristics of the classification
1 ) double-layer suppository: one is the inner and outer layers containing different drugs, the other is the upper and lower
layers, respectively, using water-soluble or fat-soluble matrix, separate different drugs in different layers, control each The
layer dissolves, giving the drug a different release rate.
2 ) hollow plug: can achieve the purpose of rapid release. The hollow portion is filled with a variety of different solid or
liquid drugs, and the dissolution rate is faster than ordinary suppositories.
3 ) control, slow release plug: microcapsule type, skeleton type, osmotic pump type [medicine.. education network collection and processing], gel sustained release type.
solid at normal temperature. After being inserted into the cavity, it can rapidly soften or dissolve in the secretion at body
temperature, and gradually release the drug to produce local or systemic effects. In the early days, it was thought that
suppositories only played a local role such as lubrication, convergence, antibacterial, insecticidal, local anesthesia, etc.
Later, it was found that suppositories can still exert systemic effects through rectal absorption of drugs, and can avoid the
first-pass effect of the liver.
Differently divided into rectal, vaginal, urethral suppositories, such as anal plugs, vaginal suppositories, urethral plugs,
dental plugs, etc., the most commonly used are anal plugs and vaginal plugs. In order to adapt to the application site of the body, the properties and weight of the suppository are different, and generally have clear regulations.
1 )anal plug The anal plug has a conical shape, a cylindrical shape, a torpedo shape and the like. Each weight is about 2g, 3-4cm long, and about 1g for children. Among them, the shape of the torpedo is better, and after being inserted into the anus, it is easily pressed into the rectum due to contraction of the sphincter. The drug in the anal plug can only exert a local therapeutic effect.
2） vaginal suppository vaginal suppository has a spherical shape, oval shape, duckbill shape, etc., each weight about 2-5g, diameter 1.5-2.5cm, which has the largest surface area of the duckbill.
3 ) urethral plug has men and women, male weight of about 4g, length 1-1.5cm; female weight of about 2g, length 0.60-0.75cm. The weight of the above suppository is made of cocoa butter, and the weight of the suppository is different if the specific gravity of the matrix is different.
According to the preparation process and release characteristics of the classification
1 ) double-layer suppository: one is the inner and outer layers containing different drugs, the other is the upper and lower
layers, respectively, using water-soluble or fat-soluble matrix, separate different drugs in different layers, control each The
layer dissolves, giving the drug a different release rate.
2 ) hollow plug: can achieve the purpose of rapid release. The hollow portion is filled with a variety of different solid or
liquid drugs, and the dissolution rate is faster than ordinary suppositories.
3 ) control, slow release plug: microcapsule type, skeleton type, osmotic pump type [medicine.. education network collection and processing], gel sustained release type.
Specification
The continuous suppository production line has a stable and efficient preheating mold, heating mold, forming mold, belt making, filling, freezing, sealing and other production processes to complete the whole process of bolting, with a production capacity of 10,000-12,000/hour.
Process flow The coiled packaging material (PVC/PE) enters the forming zone through the clamping mechanism through the preheating mold→heating mold→type mold→blowing mold→bubble forming. Filling Buried filling is used to fill the forming suppository once, the filling accuracy is ±2%, the filling barrel is equipped with electric heating and heat preservation system, and the top is equipped with a stirring motor to make the medicine in a uniform state, and the medicine in the barrel is The high-precision filling pump enters the filling head, and after one filling, the remaining medicine is circulated through the other end to the raw material barrel for the next filling. Cooling stereotype The continuous cooling system cools the suppository drug. Sealing The cooled solid suppository enters the sealing area: preheating mold (preheating) → sealing mold (sealing) coding mold (batch number) → triangle knife trimming process (cutting bottom edge) → dotted knife cutting (tearing line) ) → Hob (trim upper side) → Count cut. Continuous suppository production line Continuous shell, continuous circulating cooling, continuous finished cutting
Process flow The coiled packaging material (PVC/PE) enters the forming zone through the clamping mechanism through the preheating mold→heating mold→type mold→blowing mold→bubble forming. Filling Buried filling is used to fill the forming suppository once, the filling accuracy is ±2%, the filling barrel is equipped with electric heating and heat preservation system, and the top is equipped with a stirring motor to make the medicine in a uniform state, and the medicine in the barrel is The high-precision filling pump enters the filling head, and after one filling, the remaining medicine is circulated through the other end to the raw material barrel for the next filling. Cooling stereotype The continuous cooling system cools the suppository drug. Sealing The cooled solid suppository enters the sealing area: preheating mold (preheating) → sealing mold (sealing) coding mold (batch number) → triangle knife trimming process (cutting bottom edge) → dotted knife cutting (tearing line) ) → Hob (trim upper side) → Count cut. Continuous suppository production line Continuous shell, continuous circulating cooling, continuous finished cutting
Packing & Delivery
Company Profile
Sino Pharmaceutical Equipment Development (Liaoyang) Co., Ltd. (SINOPED) is a professional manufacturer and supplier of pharmaceutical and chemical machinery and equipment in China. We have a well-experienced team to manufacture pharmaceutical machinery and equipment and a professional design institute.
With rich experience in pharmaceutical machinery and equipment field and numbers of professional engineers, we have designed and developed many types of machinery and equipment in many varieties. Our main products are glass-lined reactors, centrifuges, granulators, mixers, dryers, pulverizers, tablet presses, blister packing machines, capsule filling machines, cartoners .
In the past years, we have made great achievements due to our good credit and service. We have established long-term business relations with many customers and some of our overseas customers have appointed us to be their purchase agency in China.
Our products are exported to many countries & areas, such as Korea, India, Indonesia, Pakistan, Thailand, Vietnam, Japan, Denmark, Romania, Bulgaria, Russia, South Africa, Nigeria, the USA, Australia, Canada, Argentina and Chile. Besides machinery and equipment, we also supply production lines, turn key projects and know-how.
In SINOPED you can get your desired goods with the best prices and good quality. We welcome your enquiries from at home and abroad.
Why choose us
Feedback
FAQ
One-year warranty period for whole machine except of tubes and human factors etc, and 12-month of after-sale service from the date when you receive machine or 12 months when installation finished;
Consultant services for whole machine life, and 24 hours technical support by email;
UPS, English software, user manual and the installation & debugging by our experienced technicians.
1. Can your machine meet our need well?
We will supply you a proposal as to your specific requirement, and each machine is customized to satisfy customer's need well.
2. Are you a factory or a trading company?
We are the manufacturer, and have been in industry for more than ten years.
3. What's your payment way?
T/T by our bank account directly, or by Alibaba's trade assurance service, or by the West Union, or in cash.
4. How can you ensure the machine's quality after we put the order?
Before the delivery, we will send you machine's pictures and videos, or you can come to us to have the quality checking by
yourself, or by the third party inspection organization contacted by your side.
5. We are afraid you won't deliver us the machine after we pay you the money.
Please note our above business license and certificates. And if you don't trust us, you can use Alibaba's trade assurance service or by LC.
6. Why choose your company?
We have been engaged in the manufacturing of various packing machines professionally over 10 years, and we can provide better after-sales service.
Consultant services for whole machine life, and 24 hours technical support by email;
UPS, English software, user manual and the installation & debugging by our experienced technicians.
1. Can your machine meet our need well?
We will supply you a proposal as to your specific requirement, and each machine is customized to satisfy customer's need well.
2. Are you a factory or a trading company?
We are the manufacturer, and have been in industry for more than ten years.
3. What's your payment way?
T/T by our bank account directly, or by Alibaba's trade assurance service, or by the West Union, or in cash.
4. How can you ensure the machine's quality after we put the order?
Before the delivery, we will send you machine's pictures and videos, or you can come to us to have the quality checking by
yourself, or by the third party inspection organization contacted by your side.
5. We are afraid you won't deliver us the machine after we pay you the money.
Please note our above business license and certificates. And if you don't trust us, you can use Alibaba's trade assurance service or by LC.
6. Why choose your company?
We have been engaged in the manufacturing of various packing machines professionally over 10 years, and we can provide better after-sales service.